The closest airport, to Hood River is in Portland (PDX). It's about a 45 minute drive. The Portland Airport is relatively small, however, so you may have more options in you fly into Seattle (SEA). Seattle is approximately a 3.5 hour drive away, but it's scenic.
The bride and groom welcome everyone to join us at the Best Western Hood River. It is the largest hotel in the area, however, it books quickly and they do not offer room blocks. We recommending booking a room ASAP if you intend to stay here.
The Hampton Inn is another great option for a hotel in Hood River. It is very close to the Best Western (there is a small trail between them) and walking distance to great restaurants and breweries!
There are a number of airbnbs available in Hood River, if you'd prefer to book one of those. Again, they fill up quickly so we'd recommend booking as soon as you're able. Wedding shuttles will pick up and drop off at the Best Western Hood River, so it is recommended to book something in this general area as Uber/Lyft is not abundant.
We'd imagine that many of you will want to make a vacation out of this trip. The bride has created a list of recommendations across Oregon, Washington, and Canada to get you started.